The discovery and development of liraglutide and semaglutide
LB Knudsen, J Lau - Frontiers in endocrinology, 2019 - frontiersin.org
The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …
bipolar disorders and other psychotic disorders. However, they might cause metabolic …
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
Management of type 2 diabetes: new and future developments in treatment
AA Tahrani, CJ Bailey, S Del Prato, AH Barnett - The Lancet, 2011 - thelancet.com
The increasing prevalence, variable pathogenesis, progressive natural history, and
complications of type 2 diabetes emphasise the urgent need for new treatment strategies …
complications of type 2 diabetes emphasise the urgent need for new treatment strategies …
Activation of the GLP-1 receptor by a non-peptidic agonist
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases,
including diabetes and obesity. Structures of active receptors reveal peptide agonists …
including diabetes and obesity. Structures of active receptors reveal peptide agonists …
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
G Song, D Yang, Y Wang, C De Graaf, Q Zhou, S Jiang… - Nature, 2017 - nature.com
The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are
members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and …
members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and …
Regulation of glucose homeostasis by GLP-1
P Nadkarni, OG Chepurny, GG Holz - Progress in molecular biology and …, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) is a secreted peptide that acts as a
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
[HTML][HTML] Gut hormones and appetite control: a focus on PYY and GLP-1 as therapeutic targets in obesity
A De Silva, SR Bloom - Gut and liver, 2012 - ncbi.nlm.nih.gov
The global obesity epidemic has resulted in significant morbidity and mortality. However, the
medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but …
medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but …
A small-molecule oral agonist of the human glucagon-like peptide-1 receptor
DA Griffith, DJ Edmonds, JP Fortin… - Journal of Medicinal …, 2022 - ACS Publications
Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized
diabetes therapy, but their use has been limited because they require injection. Herein, we …
diabetes therapy, but their use has been limited because they require injection. Herein, we …
The structure and function of the glucagon‐like peptide‐1 receptor and its ligands
D Donnelly - British journal of pharmacology, 2012 - Wiley Online Library
Glucagon‐like peptide‐1 (7‐36) amide (GLP‐1) is a 30‐residue peptide hormone released
from intestinal L cells following nutrient consumption. It potentiates the glucose‐induced …
from intestinal L cells following nutrient consumption. It potentiates the glucose‐induced …