Introduction: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2. 1.1), CA IX
and XII, involved in complex processes connected to tumorigenesis (pH regulation …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Introduction: Human carbonic anhydrases (CA, EC 4.2. 1.1) IX and XII are tumor-associated
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …

Hypoxia and acidosis are salient features of many tumors, leading to a completely different
metabolism compared to normal cells. Two of the simplest metabolic products, protons and …

Introduction: Of the 15 human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms known to date,
for 11 the crystal structure is known. Many different classes of CA inhibitors (CAIs) were …

Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …

Due to their high reaction rate and reliable selectivity, bioorthogonal click reactions have
been extensively investigated in numerous research fields, such as nanotechnology, drug …

Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)
thiazolidin-2-ylidene) amino) benzenesulfonamides (4a-m and 7a-g). All the newly prepared …

Purpose Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for
the formation of aromatic C–18 F bonds. This minireview examines proof-of-concept …

Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …