The selective exchange of ions across cellular membranes is a vital biological process.
Ca2+-mediated signaling is implicated in a broad array of physiological processes in cells …

Skeletal muscle contractions are initiated by action potentials, which are sensed by the
voltage-gated calcium channel (CaV1. 1) and are conformationally coupled to calcium …

Although COVID-19 transmission has been reduced by the advent of vaccinations and a
variety of rapid monitoring techniques, the SARS-CoV-2 virus itself has shown a remarkable …

The lower respiratory system serves as the target and barrier for beta‐coronavirus (beta‐
CoV) infections. In this study, we explored beta‐CoV infection dynamics in human bronchial …

The envelope (E) protein is a small polypeptide that can form ion channels in coronaviruses.
In SARS coronavirus 2 (SARS-CoV-2), the agent that caused the recent COVID-19 …

A key capability of ion channels is the facilitation of selective permeation of certain ionic
species across cellular membranes at high rates. Due to their physiological significance, ion …

I declare that this thesis is based on results obtained from research which I have personally
carried out in the School of Life Sciences at the University of Dundee. I declare that the …