An appropriate diagnostic evaluation is essential for the most appropriate treatment to be
performed. Currently, macroprolactinemia is the third most frequent cause of …

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and
they represent an important cause of hypogonadism and infertility in both sexes. The …

The definition of the etiology of hyperprolactinemia often represents a great challenge and
an accurate diagnosis is paramount before treatment. Although prolactin levels> 200-250 …

Hyperprolactinemia (hPRL) often poses a diagnostic dilemma due to the presence of
macroprolactin. Understanding the prevalence of macroprolactinemia (mPRL) has an …

The role of macroprolactinemia in women with hyperprolactinemia is currently controversial
and can lead to clinical dilemmas, depending upon the origin of macroprolactin, the …

Elevated prolactin levels seem to be associated with impaired sexuality. The clinical
significance of macroprolactinemia, associated with the predominance of high molecular …

Abstract Hyperprolactinemia occurs in 15–20% of women with menstrual disturbances and
30–40% of infertile women and it can adversely affect the fertility. High molecular weight …

Macroprolactin is an antigen–antibody complex of higher molecular mass than prolactin (>
150 kDa), consisting of monomeric prolactin and immunoglobulin G. The term …

Data on the prevalence of macroprolactinemia in patients with prolactinomas is quite limited
as the presence of high-molecular prolactin forms is suspected mainly in subjects with mild …

Objective: To review the current literature regarding the prevalence of macroprolactin
(macroPRL) in hyperprolactinemic patients and determine recommendations for testing …