cGAS–STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control
N Perumal, B White, F Sanchez-Valdez… - The Journal of …, 2023 - journals.aai.org
Host cell invasion by Trypanosoma cruzi is a markedly silent process, with limited host
transcriptional changes indicative of innate immune recognition, except for a modest type I …
transcriptional changes indicative of innate immune recognition, except for a modest type I …
New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease
SMF Murta, PA Lemos Santana… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Benznidazole, the drug of choice for treating Chagas Disease (CD), has
significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD …
significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD …
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
S Jayawardhana, AI Ward, AF Francisco… - PLoS …, 2023 - journals.plos.org
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
Validation of a multiplex microsphere immunoassay for detection of antibodies to Trypanosoma cruzi in dogs
CA Rodriguez, RE Busselman, H Shen… - Journal of …, 2023 - journals.sagepub.com
The vector-borne protozoan parasite Trypanosoma cruzi causes Chagas disease in
humans, dogs, and many other mammalian hosts. Canine Chagas disease is increasingly …
humans, dogs, and many other mammalian hosts. Canine Chagas disease is increasingly …
Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis
ELBC Domingues, E Gonçalves-Santos… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Phenothiazines inhibit antioxidant enzymes in trypanosomatids. However, potential
interferences with host cell antioxidant defenses are central concerns in using these drugs to …
interferences with host cell antioxidant defenses are central concerns in using these drugs to …
Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi
S Lim, S Collins, SA Hamer, RL Tarleton… - Journal of Veterinary …, 2024 - Wiley Online Library
Trypanosoma cruzi infection in dogs can cause heart failure and sudden death with few
treatment options available. A litter of 4 dogs living in a T cruzi endemic area were …
treatment options available. A litter of 4 dogs living in a T cruzi endemic area were …
Validation of a multiplex microsphere immunoassay for detection of Trypanosoma cruzi antibodies in dogs
CA Rodriguez, RE Busselman, H Shen, AB Saunders… - bioRxiv, 2023 - biorxiv.org
The vector-borne protozoan parasite Trypanosoma cruzi causes Chagas disease in
humans, dogs, and many other mammalian hosts. Canine Chagas disease is increasingly …
humans, dogs, and many other mammalian hosts. Canine Chagas disease is increasingly …
The Unfortunate Abundance of Trypanosoma cruzi in Naturally Infected Dogs and Monkeys Provides Unique Opportunities to Advance Solutions for Chagas Disease
RL Tarleton, AB Saunders, B Lococo, MGA Gianni… - Zoonoses, 2024 - scienceopen.com
Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, is widely
distributed in many vertebrate and triatomine species throughout North, Central, and South …
distributed in many vertebrate and triatomine species throughout North, Central, and South …
Trypanosoma cruzi persisters that survive benznidazole treatment in vitro and in vivo are in a transient non-replicative state
S Jayawardhana, AI Ward, AF Francisco, MD Lewis… - bioRxiv, 2023 - biorxiv.org
Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
causative agent of Chagas disease. However, for reasons that are unknown, treatment …
Health Consequences Among COVID-19 Convalescent Patients 30 Months Post-Infection in China
Y Yin, YB Guo, M Xiao, Q Chen, P Long, X Wang… - Zoonoses, 2024 - scienceopen.com
Objective: The health consequences among COVID-19 convalescent patients 30 months
post-infection were described and the potential risk factors were determined. Methods: In …
post-infection were described and the potential risk factors were determined. Methods: In …