The most striking and general property of the biological fibrous architectures in the
extracellular matrix (ECM) is the strong and directional interaction between biologically …

In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …

Valvular interstitial cells (VICs) are key regulators of the heart valve's extracellular matrix
(ECM), and upon tissue damage, quiescent VIC fibroblasts become activated to …

Valvular heart disease is currently treated with mechanical valves, which benefit from
longevity, but are burdened by chronic anticoagulation therapy, or with bioprosthetic valves …

Abstract Development of tissue engineered scaffolds for cardiac valve replacement is
nearing clinical translation. While much work has been done to characterize mechanical …

The mechanisms behind in-stent restenosis, the re-narrowing of a stented artery, are poorly
understood. However it is known that mechanical damage due to stent implantation plays a …

Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing
robust cardiovascular tissue engineering strategies, which enable synthetic or biological …

Although xenograft biomaterials have been used for decades in replacement heart valves,
they continue to face multiple limitations, including limited durability, mineralization, and …

Objectives This study aimed to develop a simple and efficient numerical modeling approach
for characterizing strain and total strain energy in bone scaffolds implanted in patient …

In the past decades, vascular tissue engineering has made great strides towards bringing
engineered vascular tissues to the clinics and, in parallel, obtaining in-lab tools for basic …