[HTML][HTML] Priorities for cancer research in low-and middle-income countries: a global perspective
Cancer research currently is heavily skewed toward high-income countries (HICs), with little
research conducted in, and relevant to, the problems of low-and middle-income countries …
research conducted in, and relevant to, the problems of low-and middle-income countries …
[HTML][HTML] Advances in oral drug delivery
The oral route is the most common route for drug administration. It is the most preferred
route, due to its advantages, such as non-invasiveness, patient compliance and …
route, due to its advantages, such as non-invasiveness, patient compliance and …
[HTML][HTML] How much does it cost to research and develop a new drug? A systematic review and assessment
M Schlander, K Hernandez-Villafuerte, CY Cheng… - …, 2021 - Springer
Background Debate over the viability of the current commercial research and development
(R&D) model is ongoing. A controversial theme is the cost of bringing a new molecular entity …
(R&D) model is ongoing. A controversial theme is the cost of bringing a new molecular entity …
Research and development spending to bring a single cancer drug to market and revenues after approval
V Prasad, S Mailankody - JAMA internal medicine, 2017 - jamanetwork.com
Importance A common justification for high cancer drug prices is the sizable research and
development (R&D) outlay necessary to bring a drug to the US market. A recent estimate of …
development (R&D) outlay necessary to bring a drug to the US market. A recent estimate of …
An arm and a leg: the rising cost of cancer drugs and impact on access
NB Leighl, S Nirmalakumar, DA Ezeife… - American Society of …, 2021 - ascopubs.org
Increasing cancer drug prices present global challenges to treatment access and cancer
outcomes. Substantial variability exists in drug pricing across countries. In countries without …
outcomes. Substantial variability exists in drug pricing across countries. In countries without …
Anticancer drugs approved by the US food and drug administration from 2009 to 2020 according to their mechanism of action
Importance Both novel and next-in-class cancer drugs have a role in oncology, but the
relative development of each is understudied. Objective To characterize the mechanisms of …
relative development of each is understudied. Objective To characterize the mechanisms of …
[HTML][HTML] Endophytic fungi—alternative sources of cytotoxic compounds: a review
Cancer is a major cause of death worldwide, with an increasing number of cases being
reported annually. The elevated rate of mortality necessitates a global challenge to explore …
reported annually. The elevated rate of mortality necessitates a global challenge to explore …
[HTML][HTML] When should we order a next generation sequencing test in a patient with cancer?
R Colomer, R Mondejar, N Romero-Laorden… - …, 2020 - thelancet.com
Technical advances in genome sequencing and the implementation of next-generation
sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient …
sequencing (NGS) in clinical oncology have paved the way for individualizing cancer patient …
[HTML][HTML] Practical considerations in screening for genetic alterations in cholangiocarcinoma
TS Bekaii-Saab, J Bridgewater, N Normanno - Annals of Oncology, 2021 - Elsevier
Cholangiocarcinoma (CCA) encompasses diverse epithelial tumors historically associated
with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit …
with poor outcomes due to an aggressive disease course, late diagnosis, and limited benefit …
[HTML][HTML] Understanding LAG-3 signaling
Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple
biological activities over T cell activation and effector functions. LAG-3 plays a regulatory …
biological activities over T cell activation and effector functions. LAG-3 plays a regulatory …