Publisher Summary This chapter reviews the histopathologic, serologic, lymphocytic,
virological, hormonal, and genetic characteristics of murine models of systemic lupus …

The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the
progressive accumulation of large numbers of non-malignant CD4-CD8-T lymphocytes. The …

Objective Umbilical cord (UC)–derived mesenchymal stem cells (MSCs) have shown
marked therapeutic effects in a number of diseases in animal studies, based on their …

The most prevalent severe manifestation of systemic lupus erythematosus is nephritis, which
is characterized by immune complex deposition, inflammation, and scarring in glomeruli and …

It is generally accepted that human Th cells express the surface glycoproteins CD4 and
alpha/beta-chain heterodimer of the TCR whereas cytotoxic/suppressor cells are usually …

Recent studies indicate that IFN-α is involved in pathogenesis of systemic lupus
erythematosus. However, direct proof that IFN-α is not only necessary, but also sufficient to …

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. To
investigate the capacity of lupus autoAb to produce glomerular immune deposits (ID) and …

Lupus nephritis is a major complication of systemic lupus erythematosus (SLE) and is
associated with a high rate of morbidity and mortality. While many different immunologic and …

Systemic lupus erythematosus (SLE) is considered to be the quintessential autoimmune
disease. It has not been possible to induce SLE in animal models by DNA immunization or …

The processes that govern the generation of pathogenic anti-DNA autoantibodies in human
systemic lupus erythematosus (SLE) are largely unknown. Autoantibodies may arise as a …