Amyloid beta: structure, biology and structure-based therapeutic development

G Chen, T Xu, Y Yan, Y Zhou, Y Jiang… - Acta pharmacologica …, 2017 - nature.com
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Galantamine: a review of its use in Alzheimer's disease

LJ Scott, KL Goa - Drugs, 2000 - Springer
Currently, acetylcholinesterase (AChE) inhibitors are the most promising class of drugs for
the treatment of Alzheimer's disease (AD). Galantamine is a reversible, competitive, tertiary …

Socio-economic aspects of Alzheimer's disease

P Maresova, H Mohelska, J Dolejs… - Current Alzheimer …, 2015 - ingentaconnect.com
Social development, better living conditions and medical advances lead to the fact that more
people have the opportunity to live longer than in the past. The aging population is a …

Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer's disease: Current trends and future perspectives

L La Barbera, E Mauri, M D'Amelio… - Frontiers in neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Early identification and treatment of Alzheimer's disease: social and fiscal outcomes

DL Weimer, MA Sager - Alzheimer's & Dementia, 2009 - Elsevier
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disease that
places substantial burdens on those who provide support for family members with declining …

A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer's disease

WJ Deardorff, GT Grossberg - Drug design, development and …, 2016 - Taylor & Francis
Currently available therapies for the treatment of Alzheimer's disease (AD) consist of
cholinesterase inhibitors (ChEIs), such as donepezil, and the N-methyl-D-aspartate receptor …

Alzheimer's disease and related dementias increase costs of comorbidities in managed Medicare

JW Hill, R Futterman, S Duttagupta, V Mastey… - Neurology, 2002 - AAN Enterprises
Objectives: To analyze the relationship between comorbid conditions and costs for patients
with AD and related dementias (ADRD) in a Medicare managed care organization (MCO) …

[PDF][PDF] Prevalence, costs, and treatment of Alzheimer's disease and related dementia: a managed care perspective

DP Rice, HM Fillit, W Max, DS Knopman… - American Journal of …, 2001 - academia.edu
Background: The number of patients with Alzheimer's disease (AD) and related dementia
treated in managed care organizations (MCOs) is increasing, and this trend is expected to …

Economic considerations in the management of Alzheimer's disease

CW Zhu, M Sano - Clinical interventions in aging, 2006 - Taylor & Francis
Alzheimer's disease is a devastating chronic disease that significantly increases healthcare
costs and affects the quality of life (QoL) of the afflicted patients and their caregivers …

Pharmacotherapeutic approaches to the treatment of Alzheimer's disease

JB Standridge - Clinical therapeutics, 2004 - Elsevier
Background: Alzheimer's disease (AD), a progressive degenerative disorder of the brain, is
the most common cause of cognitive impairment in the elderly. The pharmacotherapy of AD …