Our knowledge on sodium and water homeostasis and regulation continues to evolve. A
considerable amount of new information in this area has emerged in recent years. This …

The alteration of water balance and related disorders has emerged as being strictly linked to
the state of activation of the vasopressin–aquaporin-2 (vasopressin–AQP2) pathway. The …

Among the various biological matrices used in metabolomics, urine is a biofluid of major
interest because of its non-invasive collection and its availability in large quantities …

Results In both studies, positive associations were found between uromodulin and urinary
sodium, chloride, and potassium excretion and osmolality. In SKIPOGH, 24-hour uromodulin …

The vasopressin–cAMP–osmolality axis is abnormal in autosomal dominant polycystic
kidney disease (ADPKD). In the Tolvaptan Efficacy and Safety in Management of Autosomal …

In the TEMPO 3: 4 Trial, treatment with tolvaptan, a vasopressin V2 receptor antagonist,
slowed the increase in total kidney volume and decline in estimated glomerular filtration rate …

Purpose Inter-individual variation in median plasma copeptin is associated with incident
type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events …

OBJECTIVE Plasma copeptin, a surrogate for vasopressin, has been associated with a
decline in renal function and albuminuria in population-based studies as well as with …

Context Although the physiology of sodium, water, and arginine vasopressin (AVP), also
known as antidiuretic hormone, has long been known, accumulating data suggest that this …

Mortality among the patients with chronic kidney disease (CKD) and end-stage renal
disease (ESRD) remains high because of the very high incidence of cardiovascular disease …