Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

Actin is a well-known protein that has shown a myriad of activities in the cytoplasm.
However, recent findings of actin involvement in nuclear processes are overwhelming. Actin …

Generating a catalogue of sperm nuclear proteins is an important first step towards the
clarification of the function of the paternal chromatin transmitted to the oocyte upon …

Abnormalities in nuclear phenotype and chromosome structure are key features of cancer
cells. Investigation of the protein determinants of nuclear subfractions in cancer may yield …

The nuclear matrix (NM) model posits the presence of a protein/RNA scaffold that spans the
mammalian nucleus. The NM proteins are involved in basic nuclear function and are a …

Spermatogenesis is a fundamental process in sexual development and reproduction, in
which the diploid spermatogonia transform into haploid mature spermatozoa. This process is …

Adenylyl cyclases (ACs) synthesize cAMP and are present in cells as transmembrane AC
and soluble AC (sAC). In sperm, the cAMP produced regulates ion channels and it also …

Mammalian spermatozoa contain some of the most highly compact chromatin. This is due to
the DNA binding proteins, the protamines, which replace most of the histones during …

Chronic exposure of male rats to the alkylating agent cyclophosphamide, a well-known male-
mediated developmental toxicant, alters gene expression in male germ cells as well as in …

Omics approaches are continuously providing new clues on the mechanisms of action of
contaminants in species of environmental relevance, contributing to the emergence of …