Global warming and glyphosate toxicity (I): Adult zebrafish modelling with behavioural, immunohistochemical and metabolomic approaches

E Sulukan, A Baran, O Şenol, M Kankaynar… - Science of The Total …, 2023 - Elsevier
Global warming further increases the toxic threat of environmental pollutants on organisms.
In order to reveal the dimensions of this threat more clearly, it is of great importance that the …

Transcriptome reveals granulosa cells coping through redox, inflammatory and metabolic mechanisms under acute heat stress

A Sammad, H Luo, L Hu, H Zhu, Y Wang - Cells, 2022 - mdpi.com
Heat stress affects granulosa cells (GCs) and the ovarian follicular microenvironment,
causing poor oocyte developmental competence and fertility. This study aimed to investigate …

Plasma metabolomic characterization of premature ovarian insufficiency

XY Zhou, X Li, J Zhang, Y Li, XM Wu, YZ Yang… - Journal of Ovarian …, 2023 - Springer
Background Premature ovarian insufficiency (POI) patients are predisposed to metabolic
disturbances, including in lipid metabolism and glucose metabolism, and metabolic …

Joint Transcriptome and Metabolome Analysis prevails the Biological mechanisms underlying the Pro-survival Fight in In Vitro Heat-stressed granulosa cells

A Sammad, H Luo, L Hu, S Zhao, J Gong, S Umer… - Biology, 2022 - mdpi.com
Simple Summary This study integrates the differentially expressed genes and important
metabolites found in the transcriptome and metabolome analyses of in vitro acute heat …

Integrated analysis of the expression profiles of the lncRNA-miRNA-mRNA ceRNA network in granulosa and cumulus cells from yak ovaries

L Zhao, Y Pan, M Wang, J Wang, Y Wang, X Han… - BMC genomics, 2022 - Springer
Background Growing oocytes acquire the ability to mature through two-way communication
between gametes and surrounding somatic cumulus cells (CCs). Granulosa cells (GCs) …

[HTML][HTML] Epigenomics of rats' liver and its cross-species functional annotation reveals key regulatory genes underlying short term heat-stress response

J Dou, H Luo, A Sammad, W Lou, D Wang, F Schenkel… - Genomics, 2022 - Elsevier
Molecular responses to heat stress are multifaceted and under a complex cellular post-
transcriptional control. This study explores the epigenetic and transcriptional alterations …

[HTML][HTML] Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways

Z Zhu, J Wu, Y Wen, X Wu, H Bao, M Wang, K Kang - Veterinary Sciences, 2024 - mdpi.com
Simple Summary Heat stress exerts extensive and intricate effects on germ cells, attracting
significant attention from researchers. This article provides a comprehensive review and …

Incorporation of L-Carnitine in the OvSynch protocol enhances the morphometrical and hemodynamic parameters of the ovarian structures and uterus in ewes under …

H Samir, AA Swelum, EA Abdelnaby… - BMC Veterinary …, 2023 - Springer
Heat stress negatively impacts the reproductive performance of sheep including the
efficiency of estrous synchronization regimens. This study aimed to investigate the potential …

Analysis of CircRNA Expression in Peripheral Blood of Holstein Cows in Response to Heat Stress

C Zhang, S Wang, L Hu, H Fang, G Chen, X Ma… - International Journal of …, 2023 - mdpi.com
The present study aimed to identify key circRNAs and pathways associated with heat stress
in blood samples of Holstein cows, which will provide new insights into the molecular …

Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells

A Sammad, T Ahmed, K Ullah, L Hu, H Luo… - Antioxidants, 2024 - mdpi.com
Heat stress-induced biochemical alterations in ovarian follicles compromise the function of
granulosa cells (GCs) and the developmental competence of oocytes. Summer heat stress …