Natural and targeted circuit reorganization after spinal cord injury
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
Spinal cord repair: advances in biology and technology
G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …
Advances in clinical management have decreased morbidity and improved outcomes, but …
Therapeutic potential of intermittent hypoxia: a matter of dose
A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …
triggers a bewildering array of both detrimental and beneficial effects in multiple …
Neuromechanical principles underlying movement modularity and their implications for rehabilitation
Neuromechanical principles define the properties and problems that shape neural solutions
for movement. Although the theoretical and experimental evidence is debated, we present …
for movement. Although the theoretical and experimental evidence is debated, we present …
Restoring function after spinal cord injury: towards clinical translation of experimental strategies
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …
complications and maximising residual function by rehabilitation. Improved understanding of …
Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …
strategy to improve respiratory and non-respiratory motor function in people with …
Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial
Objectives: To test the hypothesis that daily acute intermittent hypoxia (dAIH) and dAIH
combined with overground walking improve walking speed and endurance in persons with …
combined with overground walking improve walking speed and endurance in persons with …
Mechanisms of stem cell therapy in spinal cord injuries
Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …
Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function
Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …
disordered breathing, including central nervous system pathology. However, recent …
Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α
Injured peripheral neurons successfully activate a proregenerative transcriptional program
to enable axon regeneration and functional recovery. How transcriptional regulators …
to enable axon regeneration and functional recovery. How transcriptional regulators …