Natural and targeted circuit reorganization after spinal cord injury

MA Anderson, JW Squair, M Gautier, TH Hutson… - Nature …, 2022 - nature.com
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …

Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Therapeutic potential of intermittent hypoxia: a matter of dose

A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Neuromechanical principles underlying movement modularity and their implications for rehabilitation

LH Ting, HJ Chiel, RD Trumbower, JL Allen, JL McKay… - Neuron, 2015 - cell.com
Neuromechanical principles define the properties and problems that shape neural solutions
for movement. Although the theoretical and experimental evidence is debated, we present …

Restoring function after spinal cord injury: towards clinical translation of experimental strategies

LM Ramer, MS Ramer, EJ Bradbury - The Lancet Neurology, 2014 - thelancet.com
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

AK Vose, JF Welch, J Nair, EA Dale, EJ Fox… - Experimental …, 2022 - Elsevier
We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial

HB Hayes, A Jayaraman, M Herrmann, GS Mitchell… - Neurology, 2014 - AAN Enterprises
Objectives: To test the hypothesis that daily acute intermittent hypoxia (dAIH) and dAIH
combined with overground walking improve walking speed and endurance in persons with …

Mechanisms of stem cell therapy in spinal cord injuries

M Shinozaki, N Nagoshi, M Nakamura, H Okano - Cells, 2021 - mdpi.com
Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with
irretrievable sequelae. Rehabilitation, currently the only available treatment, does not …

Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function

EA Dale, F Ben Mabrouk, GS Mitchell - Physiology, 2014 - journals.physiology.org
Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …

Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α

Y Cho, JE Shin, EE Ewan, YM Oh, W Pita-Thomas… - Neuron, 2015 - cell.com
Injured peripheral neurons successfully activate a proregenerative transcriptional program
to enable axon regeneration and functional recovery. How transcriptional regulators …