Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

During the elongating spermatid stage of spermiogenesis, human sperm chromatin
undergoes a complex transition in which histones are extensively replaced by protamines in …

Abstract STUDY QUESTION Does sperm DNA damage affect early embryonic
development? SUMMARY ANSWER Increased sperm DNA damage adversely affects …

Background Infertile men have higher levels of semen reactive oxygen species (ROS) than
fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage …

DNA damage in human spermatozoa has been associated with a range of adverse clinical
outcomes, including infertility, abortion, and disease in the offspring. We have advanced a …

The exchange of histones with protamines in sperm DNA results in sperm chromatin
compaction and protection. Variations in sperm protamine expression are associated with …

The objective of this study was to examine the relationship between DNA integrity and
protamines in human sperm. One hundred forty‐nine male infertility patients were included …

Sperm protamine deficiency has been associated with human male infertility. However, most
studies have adopted a global approach to assessing sperm protamine levels. Thus, it is not …

In previous studies, a new IVF method of intracytoplasmic morphologically selected sperm
injection (IMSI) was introduced, based on motile sperm organellar morphology examination …

STUDY QUESTION Is there an association between sperm DNA damage, measured by
three different assays, sperm nuclear protein content and clinical outcomes in assisted …