In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …

Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …

Spatial transcriptomics and proteomics provide complementary information that
independently transformed our understanding of complex biological processes. However …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Diabetes is a systemic disease in which patients with diabetes may develop peripheral
neuropathy of the lower extremities and peripheral vascular disease due to long-term …

B cells within germinal centers (GCs) enter cycles of antibody affinity maturation or exit the
GC as memory cells or plasma cells. Here, we examined the contribution of interleukin (IL)-4 …

Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …