Hepatocellular carcinoma and obesity, type 2 diabetes mellitus, cardiovascular disease: causing factors, molecular links, and treatment options
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which will
affect more than a million people by the year 2025. However, current treatment options have …
affect more than a million people by the year 2025. However, current treatment options have …
Noninvasive plaque imaging to accelerate coronary artery disease drug development
Coronary artery disease (CAD) remains the leading cause of adult mortality globally.
Targeting known modifiable risk factors has had substantial benefit, but there remains a …
Targeting known modifiable risk factors has had substantial benefit, but there remains a …
A mechanistic framework for cardiometabolic and coronary artery diseases
Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …
Decoupling of the Confused Complex in Oxidation of 3, 3′, 5, 5′-Tetramethylbenzidine for the Reliable Chromogenic Bioassay
C Zhu, H Yang, X Cao, Q Hong, Y Xu, K Wang… - Analytical …, 2023 - ACS Publications
Regulation of the reaction pathways is a perennial theme in the field of chemistry. As a
typical chromogenic substrate, 3, 3′, 5, 5′-tetramethylbenzidine (TMB) generally …
typical chromogenic substrate, 3, 3′, 5, 5′-tetramethylbenzidine (TMB) generally …
[HTML][HTML] Neutral effect of SGLT2 inhibitors on lipoprotein metabolism: From clinical evidence to molecular mechanisms
Abstract Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are effective, well-tolerated,
and safe glucose-lowering compounds for patients with type 2 diabetes mellitus (T2DM) …
and safe glucose-lowering compounds for patients with type 2 diabetes mellitus (T2DM) …
A study of gene expression in the living human brain
LE Liharska, YJ Park, K Ziafat, L Wilkins, H Silk… - medRxiv, 2023 - medrxiv.org
A goal of medical research is to determine the molecular basis of human brain health and
illness. One way to achieve this goal is through observational studies of gene expression in …
illness. One way to achieve this goal is through observational studies of gene expression in …
Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial
J Liu, DD Li, W Dong, YQ Liu, Y Wu, DX Tang… - … and Targeted Therapy, 2021 - nature.com
It'sa challenge for detecting the therapeutic targets of a polypharmacological drug from
variations in the responsed networks in the differentiated populations with complex …
variations in the responsed networks in the differentiated populations with complex …
Impact of feeding dried distillers' grains with solubles diet on microbiome and metabolome of ruminal and cecal contents in Guanling yellow cattle
C Song, T Zhang, D Xu, M Zhu, S Mei, B Zhou… - Frontiers in …, 2023 - frontiersin.org
Dried distillers' grains with solubles (DDGS) are rich in nutrients, and partially alternative
feeding of DDGS effectively reduces cost of feed and improves animals' growth. We used …
feeding of DDGS effectively reduces cost of feed and improves animals' growth. We used …
Cardiac metabolism, reprogramming, and diseases
H Wang, M Shen, X Shu, B Guo, T Jia, J Feng… - Journal of …, 2024 - Springer
Cardiovascular diseases (CVD) account for the largest bulk of deaths worldwide, posing a
massive burden on societies and the global healthcare system. Besides, the incidence and …
massive burden on societies and the global healthcare system. Besides, the incidence and …
Big data and machine learning to tackle diabetes management
AF Pina, MJ Meneses, I Sousa‐Lima… - European Journal of …, 2023 - Wiley Online Library
Abstract Background Type 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even
though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is …
though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is …