The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Decades of research have shown that mutations in the p53 stress response pathway affect
the incidence of diverse cancers more than mutations in other pathways. However, most …

The p53 tumor suppressor is activated in response to cellular stresses to induce cell-cycle
arrest, cellular senescence, and apoptosis. The p53 gene is inactivated by mutations in …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Summary hnRNP K regulates cellular programs, and changes in its expression and
mutational status have been implicated in neoplastic malignancies. To directly examine its …

The ubiquitin proteasome pathway is critical in restraining the activities of the p53 tumor
suppressor. Numerous E3 and E4 ligases regulate p53 levels. Additionally, deubquitinating …

The p53 protein is a transcription factor that prevents tumors from developing. In
spontaneous and inherited cancers there are many different missense mutations in the DNA …