Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

The pathogenesis of endometriosis: molecular and cell biology insights

AS Laganà, S Garzon, M Götte, P Viganò… - International journal of …, 2019 - mdpi.com
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

[HTML][HTML] Chemically induced reprogramming to reverse cellular aging

JH Yang, CA Petty, T Dixon-McDougall… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …

Ageing as a software design flaw

JP de Magalhães - Genome Biology, 2023 - Springer
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

Functions and mechanisms of epigenetic inheritance in animals

K Skvortsova, N Iovino, O Bogdanović - Nature reviews Molecular cell …, 2018 - nature.com
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

JA Dahl, I Jung, H Aanes, GD Greggains, A Manaf… - Nature, 2016 - nature.com
Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is
still poorly understood despite recent progress in analysis of gene expression and DNA …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Cybernetic big five theory

CG DeYoung - Journal of research in personality, 2015 - Elsevier
Cybernetics, the study of goal-directed, adaptive systems, is the best framework for an
integrative theory of personality. Cybernetic Big Five Theory attempts to provide a …

[HTML][HTML] Epigenetic alterations in cancer

S Ilango, B Paital, P Jayachandran… - Frontiers in Bioscience …, 2020 - imrpress.com
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

[HTML][HTML] CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter

SR Choudhury, Y Cui, K Lubecka, B Stefanska… - Oncotarget, 2016 - ncbi.nlm.nih.gov
DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …