Molecular mechanisms of transgenerational epigenetic inheritance
MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …
inherited across several generations in organisms ranging from yeast to plants to humans …
The pathogenesis of endometriosis: molecular and cell biology insights
The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …
[HTML][HTML] Chemically induced reprogramming to reverse cellular aging
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
Ageing as a software design flaw
JP de Magalhães - Genome Biology, 2023 - Springer
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is
still poorly understood despite recent progress in analysis of gene expression and DNA …
still poorly understood despite recent progress in analysis of gene expression and DNA …
Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Cybernetic big five theory
CG DeYoung - Journal of research in personality, 2015 - Elsevier
Cybernetics, the study of goal-directed, adaptive systems, is the best framework for an
integrative theory of personality. Cybernetic Big Five Theory attempts to provide a …
integrative theory of personality. Cybernetic Big Five Theory attempts to provide a …
[HTML][HTML] Epigenetic alterations in cancer
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
[HTML][HTML] CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …
their transcriptional repression and recognized as the hallmark of majority of cancers …