A comprehensive review of SHP2 and its role in cancer
MD Asmamaw, XJ Shi, LR Zhang, HM Liu - Cellular Oncology, 2022 - Springer
Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
Q Huang, Y Zhong, H Dong, Q Zheng, S Shi… - European Journal of …, 2020 - Elsevier
As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …
then activates transcription of target genes. STAT3 has been well validated as an attractive …
Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model
Aberrant reactions of signal transducer and transcriptional activator (STAT) are frequently
detected in multiple myeloma (MM) cancers and can upregulate the expression of multiple …
detected in multiple myeloma (MM) cancers and can upregulate the expression of multiple …
Pharmacological inhibition of oncogenic STAT3 and STAT5 signaling in hematopoietic cancers
M Brachet-Botineau, M Polomski, HA Neubauer… - Cancers, 2020 - mdpi.com
Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …
STAT3: a promising therapeutic target in multiple myeloma
Multiple myeloma (MM) is an incurable plasma cell malignancy for which novel treatment
options are required. Signal Transducer and Activator of Transcription 3 (STAT3) …
options are required. Signal Transducer and Activator of Transcription 3 (STAT3) …
Genetic abnormalities in extramedullary multiple myeloma
R McAvera, J Quinn, P Murphy, S Glavey - International Journal of …, 2023 - mdpi.com
Extramedullary multiple myeloma (or extramedullary disease, EMD) is an aggressive form of
multiple myeloma (MM) that occurs when malignant plasma cells become independent of …
multiple myeloma (MM) that occurs when malignant plasma cells become independent of …
Euphorbiasteroid induces apoptosis as well as autophagy through modulating SHP-1/STAT3 pathway in hepatocellular carcinoma cells
Euphorbiasteroid (EPBS) has gained attention for its activity against human lung cancer and
sarcoma; however, its impact on hepatocellular carcinoma has not yet been elucidated …
sarcoma; however, its impact on hepatocellular carcinoma has not yet been elucidated …
Cytokine-mediated dysregulation of signaling pathways in the pathogenesis of multiple myeloma
Multiple myeloma (MM) is a hematologic disorder of B lymphocytes characterized by the
accumulation of malignant plasma cells (PCs) in the bone marrow. The altered plasma cells …
accumulation of malignant plasma cells (PCs) in the bone marrow. The altered plasma cells …
Metabolic effects of recurrent genetic aberrations in multiple myeloma
TA Bloedjes, G de Wilde, JEJ Guikema - Cancers, 2021 - mdpi.com
Simple Summary Cancer is associated with metabolic changes related to increased cell
proliferation and growth. These cancer-related metabolic features are largely dictated by …
proliferation and growth. These cancer-related metabolic features are largely dictated by …
Alteration of SHP-1/p-STAT3 signaling: a potential target for anticancer therapy
The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a
non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of …
non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of …