Brainstem circuits for locomotion
Locomotion is a universal motor behavior that is expressed as the output of many integrated
brain functions. Locomotion is organized at several levels of the nervous system, with …
brain functions. Locomotion is organized at several levels of the nervous system, with …
Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic
Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
Pedunculopontine Chx10+ neurons control global motor arrest in mice
Arrest of ongoing movements is an integral part of executing motor programs. Behavioral
arrest may happen upon termination of a variety of goal-directed movements or as a global …
arrest may happen upon termination of a variety of goal-directed movements or as a global …
Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …
Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism
D Masini, O Kiehn - Nature communications, 2022 - nature.com
The pedunculopontine nucleus (PPN) is a locomotor command area containing
glutamatergic neurons that control locomotor initiation and maintenance. These motor …
glutamatergic neurons that control locomotor initiation and maintenance. These motor …
Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease
M Fougère, CI van der Zouwen… - Proceedings of the …, 2021 - National Acad Sciences
In Parkinson's disease (PD), the loss of midbrain dopaminergic cells results in severe
locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these …
locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these …
Upregulation of breathing rate during running exercise by central locomotor circuits in mice
While respiratory adaptation to exercise is compulsory to cope with the increased metabolic
demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and …
demand, the neural signals at stake remain poorly identified. Using neural circuit tracing and …
Discussion of research priorities for gait disorders in Parkinson's disease
Gait and balance abnormalities develop commonly in Parkinson's disease and are among
the motor symptoms most disabling and refractory to dopaminergic or other treatments …
the motor symptoms most disabling and refractory to dopaminergic or other treatments …
Locomotor pattern generation and descending control: a historical perspective
R Dubuc, JM Cabelguen… - Journal of …, 2023 - journals.physiology.org
The ability to generate and control locomotor movements depends on complex interactions
between many areas of the nervous system, the musculoskeletal system, and the …
between many areas of the nervous system, the musculoskeletal system, and the …
The mesencephalic locomotor region: beyond locomotor control
The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat.
It was functionally defined based on the ability of low threshold electrical stimuli within a …
It was functionally defined based on the ability of low threshold electrical stimuli within a …