Mismatched (non-Watson–Crick) base pairs represent the most common type of DNA
damage, as they are permanently formed in living cells due to erroneous insertion, deletion …

Macrocyclic scaffolds are particularly attractive for designing selective G‐quadruplex ligands
essentially because, on one hand, they show a poor affinity for the “standard” B‐DNA …

The quest for small molecules that strongly bind to G-quadruplex-DNA (G4), so-called G4
ligands, has invigorated the G4 research field from its very inception. Massive efforts have …

In recent years, an increasing number of reports have been focused on the structure and
biological role of non-canonical nucleic acid secondary structures. Many of these studies …

DNA interaction with scorpiand azamacrocycles has been achieved through modulation of
their binding affinities. Studies performed with different experimental techniques provided …

Studies on DNA–ligand interactions in the cellular environment are problematic due to the
lack of suitable biophysical tools. To address this need, we developed an in-cell NMR-based …

Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X= C, A,
G and T) sequences in genomes. We have reported two small molecules binding to TNR …

The first racemization-stable helicene derivatives fluorinated at terminal rings, 1, 2, 3, 4-
tetrafluoro [6] helicene (6) and 1, 2, 3, 4, 13, 14, 15, 16-octafluoro [6] helicene (15), were …

Many natural products consist of large and flexible macrocycles that engage their targets via
multiple contact points. This combination of contained flexibility and large contact area often …

Pyrene‐based cyclophanes have been synthesized with the aim to realize a bellows‐type
sensing mechanism for the ratiometric detection of nucleotide concentrations in a buffered …