Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …

Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the
molecular mechanisms driving this plasticity remain unclear. Using murine organoid and …

The functions of the tumor microenvironment (TME) are orchestrated by precise spatial
organization of specialized cells, yet little is known about the multicellular structures that …

Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …

Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of
tumor cells that have acquired endothelial-like properties. VM channels endow the tumor …

Mass cytometry (cytometry by time-of-flight detection [CyTOF]) is a bioanalytical technique
that enables the identification and quantification of diverse features of cellular systems with …

Breast tumor heterogeneity is a major challenge in the clinical management of breast cancer
patients. Both inter-tumor and intra-tumor heterogeneity imply that each breast cancer (BC) …

Multiplex immunophenotyping of cell surface proteomes is useful for cell characterization as
well as providing valuable information on a patient's physiological or pathological state …

Breast cancer is well-known to be a highly heterogenous disease. This facet of cancer
makes finding a research model that mirrors the disparate intrinsic features challenging …