Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
VEGF targets the tumour cell
HL Goel, AM Mercurio - Nature Reviews Cancer, 2013 - nature.com
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2
D Zhao, C Pan, J Sun, C Gilbert, K Drews-Elger… - Oncogene, 2015 - nature.com
Vascular endothelial growth factor-A (VEGF), a potent angiogenic factor, is also implicated in
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
[HTML][HTML] Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death
M Castells, B Thibault, JP Delord… - International journal of …, 2012 - mdpi.com
Tumor development principally occurs following the accumulation of genetic and epigenetic
alterations in tumor cells. These changes pave the way for the transformation of …
alterations in tumor cells. These changes pave the way for the transformation of …
[HTML][HTML] Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
S Chatterjee, LC Heukamp, M Siobal… - The Journal of …, 2013 - Am Soc Clin Investig
The molecular mechanisms that control the balance between antiangiogenic and
proangiogenic factors and initiate the angiogenic switch in tumors remain poorly defined. By …
proangiogenic factors and initiate the angiogenic switch in tumors remain poorly defined. By …
Tumor microenvironment: a new treatment target for cancer
MJ Tsai, WA Chang, MS Huang… - International Scholarly …, 2014 - Wiley Online Library
Recent advances in cancer therapy encounter a bottleneck. Relapsing/recurrent disease
almost always developed eventually with resistance to the initially effective drugs. Tumor …
almost always developed eventually with resistance to the initially effective drugs. Tumor …
[HTML][HTML] Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways
HC Pal, S Sharma, LR Strickland, J Agarwal, M Athar… - PloS one, 2013 - journals.plos.org
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2
(VEGFR2) have emerged as two effective clinical targets for non-small-cell lung cancer …
(VEGFR2) have emerged as two effective clinical targets for non-small-cell lung cancer …
[HTML][HTML] HBO1 induces histone acetylation and is important for non-small cell lung cancer cell growth
T Chen, H Hao, Y Zhang, X Chen, H Zhao… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
We examined the expression and the potential biological function of HBO1 in non-small cell
lung cancer (NSCLC). TCGA and Oncomine databases showed that HBO1 transcripts were …
lung cancer (NSCLC). TCGA and Oncomine databases showed that HBO1 transcripts were …
[HTML][HTML] Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD
S Yoo, S Takikawa, P Geraghty, C Argmann… - PLoS …, 2015 - journals.plos.org
Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic,
and environmental factors are known to contribute to COPD risk and disease progression …
and environmental factors are known to contribute to COPD risk and disease progression …
[HTML][HTML] Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma
E Riquelme, MB Suraokar, J Rodriguez, B Mino… - Journal of Thoracic …, 2014 - Elsevier
Introduction: Malignant pleural mesothelioma (MPM) is a deadly disease with poor
prognosis and few treatment options. We characterized and elucidated the roles of C-MYC …
prognosis and few treatment options. We characterized and elucidated the roles of C-MYC …