Inflammation and oxidative stress in diabetic kidney disease: the targets for SGLT2 inhibitors and GLP-1 receptor agonists
A Winiarska, M Knysak, K Nabrdalik… - International Journal of …, 2021 - mdpi.com
The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …
The impact of SGLT2 inhibitors on inflammation: A systematic review and meta-analysis of studies in rodents
Background Inhibition of sodium-glucose cotransporter-2 (SGLT2) has received remarkable
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …
Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial
MN Kosiborod, R Esterline, RHM Furtado… - The lancet Diabetes & …, 2021 - thelancet.com
Background COVID-19 can lead to multiorgan failure. Dapagliflozin, a SGLT2 inhibitor, has
significant protective benefits for the heart and kidney. We aimed to see whether this agent …
significant protective benefits for the heart and kidney. We aimed to see whether this agent …
Effects of dapagliflozin on mortality in patients with chronic kidney disease: a pre-specified analysis from the DAPA-CKD randomized controlled trial
HJL Heerspink, CD Sjöström, N Jongs… - European heart …, 2021 - academic.oup.com
Aims Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In
this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin …
this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin …
Comparative Effectiveness of Sodium–Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and …
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is) decrease serum urate
levels, but whether this translates into prevention of recurrent flares among patients with …
levels, but whether this translates into prevention of recurrent flares among patients with …
Effects of dapagliflozin on prevention of major clinical events and recovery in patients with respiratory failure because of COVID‐19: Design and rationale for the …
M Kosiborod, O Berwanger, GG Koch… - Diabetes, Obesity …, 2021 - Wiley Online Library
Abstract Aims Coronavirus disease 2019 (COVID‐19) is caused by a novel severe acute
respiratory syndrome coronavirus 2. It can lead to multiorgan failure, including respiratory …
respiratory syndrome coronavirus 2. It can lead to multiorgan failure, including respiratory …
Empagliflozin and uric acid metabolism in diabetes: a post hoc analysis of the EMPA‐REG OUTCOME trial
JP Ferreira, SE Inzucchi, M Mattheus… - Diabetes, Obesity …, 2022 - Wiley Online Library
Aim To evaluate the effect of empagliflozin on uric acid (UA) levels, antigout medication and
gout episodes in the EMPA‐REG OUTCOME trial (NCT01131676). Materials and methods A …
gout episodes in the EMPA‐REG OUTCOME trial (NCT01131676). Materials and methods A …
Tubular cell glucose metabolism shift during acute and chronic injuries
Acute and chronic kidney disease are responsible for large healthcare costs worldwide.
During injury, kidney metabolism undergoes profound modifications in order to adapt to …
During injury, kidney metabolism undergoes profound modifications in order to adapt to …
[HTML][HTML] Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis
Aims Sepsis is a life-threatening condition of organ dysfunction caused by dysregulated
inflammation which predisposes patients to developing cardiovascular disease. The ketone …
inflammation which predisposes patients to developing cardiovascular disease. The ketone …
Sodium-glucose transport protein 2 inhibitor use for type 2 diabetes and the incidence of acute kidney injury in Taiwan
MC Chung, PH Hung, PJ Hsiao, LY Wu… - JAMA Network …, 2023 - jamanetwork.com
Importance The association between sodium-glucose transport protein 2 inhibitor (SGLT2i)
use and the incidence of acute kidney injury (AKI) remains controversial. The benefits of …
use and the incidence of acute kidney injury (AKI) remains controversial. The benefits of …