[HTML][HTML] Advances in the treatment of Chagas disease: Promising new drugs, plants and targets

P García-Huertas, N Cardona-Castro - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …

Review of pharmacological options for the treatment of Chagas disease

F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

The potential of secondary metabolites from plants as drugs or leads against trypanosoma cruzi-an update from 2012 to 2021

H Barbosa, F Thevenard… - Current Topics in …, 2023 - ingentaconnect.com
Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …

[HTML][HTML] Plant terpenoids as hit compounds against trypanosomiasis

R Durão, C Ramalhete, AM Madureira, E Mendes… - Pharmaceuticals, 2022 - mdpi.com
Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis
(Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan …

The specialized sesquiterpenoids produced by the genus Elephantopus L.: Chemistry, biological activities and structure-activity relationship exploration

QR Rao, JB Rao, M Zhao - Phytochemistry, 2024 - Elsevier
The genus Elephantopus L. is a valuable resource rich in sesquiterpenoids with structural
diversity and various bioactivities, showing great potential for applications in medicinal field …

[PDF][PDF] In-vivo and in-silico evidence of anti-trypanocidal activities of selected plants from Asteraceae family against Trypanosoma brucei brucei

CO Nnadi, SO Ngwu… - … Research in Applied …, 2023 - biointerfaceresearch.com
The menace of animal African trypanosomiasis (AAT) has increased in sub-Saharan Africa
despite countless interventions through chemotherapy and health policies. The study …

[HTML][HTML] Chagas heart disease: beyond a single complication, from asymptomatic disease to heart failure

IG Montalvo-Ocotoxtle, G Rojas-Velasco… - Journal of Clinical …, 2022 - mdpi.com
Chagas cardiomyopathy (CC), caused by the protozoan Trypanosoma cruzi, is an important
cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 …

Cynaropicrin attenuates inflammatory cytokines in LPS‐induced RAW264. 7 cells and ovalbumin‐induced asthmatic mice

J Chen, X Liu - Journal of Biochemical and Molecular …, 2024 - Wiley Online Library
This study examines the anti‐inflammatory activity of cynaropicrin against
lipopolysaccharide (LPS) in vitro and ovalbumin (OVA)‐challenged asthma in mice …

The chemistry of Vernonanthura nudiflora (Less.) H. Rob. flowers and its antimicrobial activities

AVG Ramos, N de Sá, DLO Araújo… - Natural Product …, 2023 - Taylor & Francis
Twenty-one known specialised metabolites were isolated from the flowers of Vernonanthura
nudiflora (Less.) H. Rob., the structures of the compounds were established based on 1 D …

Centrifugal partition chromatography isolation of glaucolides sesquiterpenes and LC-ESIMS/MS technique for differentiation the mass spectrometry behavior of …

LAL Da Silva, MW Biavatti, LP Sandjo - Studies in Natural Products …, 2022 - Elsevier
Bibliographic research has revealed that several sesquiterpene lactones (SLs) can
reorganize their hydrocarbon structure during chromatographic purification in the solid …