TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Advances in quantum dot-based biosensors for DNA-modifying enzymes assay
Q Zhang, X Zhang, F Ma, C Zhang - Coordination Chemistry Reviews, 2022 - Elsevier
DNA-modifying enzymes participate in various genetic functions (eg, DNA replication,
repairing, and recombination) through alternating certain DNA sequence, and the …
repairing, and recombination) through alternating certain DNA sequence, and the …
[HTML][HTML] Reconfiguration of DNA methylation in aging
M Zampieri, F Ciccarone, R Calabrese… - Mechanisms of ageing …, 2015 - Elsevier
A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
Background DNA methylation (5mC) plays important roles in epigenetic regulation of
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
IF López-Moyado, M Ko, PG Hogan… - Annual Review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution
Recently, the cytosine modifications 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine
(5fC) were found to exist in the genomic deoxyribonucleic acid (DNA) of a wide range of …
(5fC) were found to exist in the genomic deoxyribonucleic acid (DNA) of a wide range of …
Characterizing DNA methylation alterations from the cancer genome atlas
DJ Weisenberger - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional
consortium effort aimed at characterizing sequence, copy number, gene (mRNA) …
consortium effort aimed at characterizing sequence, copy number, gene (mRNA) …
5-hydroxymethylcytosine and its potential roles in development and cancer
GP Pfeifer, S Kadam, SG Jin - Epigenetics & chromatin, 2013 - Springer
Only a few years ago it was demonstrated that mammalian DNA contains oxidized forms of 5-
methylcytosine (5mC). The base 5-hydroxymethylcytosine (5hmC) is the most abundant of …
methylcytosine (5mC). The base 5-hydroxymethylcytosine (5hmC) is the most abundant of …
Epigenetic regulation of asthma and allergic disease
P Bégin, KC Nadeau - Allergy, Asthma & Clinical Immunology, 2014 - Springer
Epigenetics of asthma and allergic disease is a field that has expanded greatly in the last
decade. Previously thought only in terms of cell differentiation, it is now evident the …
decade. Previously thought only in terms of cell differentiation, it is now evident the …