MLIP and Its Potential Influence on Key Oncogenic Pathways

MN Hamwi, E Elsayed, H Dabash, A Abuawad… - Cells, 2024 - mdpi.com
Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in
cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular …

MLIP causes recessive myopathy with rhabdomyolysis, myalgia and baseline elevated  serum creatine kinase

O Lopes Abath Neto, L Medne, S Donkervoort… - Brain, 2021 - academic.oup.com
Striated muscle needs to maintain cellular homeostasis in adaptation to increases in
physiological and metabolic demands. Failure to do so can result in rhabdomyolysis. The …

MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension

MI Canut, O Villa, B Kudsieh, H Mattlin, I Banchs… - Scientific reports, 2021 - nature.com
Predicting the therapeutic response to ocular hypotensive drugs is crucial for the clinical
treatment and management of glaucoma. Our aim was to identify a possible genetic …

Muscle Enriched Lamin Interacting Protein (Mlip) Binds Chromatin and Is Required for Myoblast Differentiation

E Ahmady, A Blais, PG Burgon - Cells, 2021 - mdpi.com
Muscle-enriched A-type lamin-interacting protein (Mlip) is a recently discovered Amniota
gene that encodes proteins of unknown biological function. Here we report Mlip's direct …

Biallelic truncating variants in the muscular A‐type lamin‐interacting protein (MLIP) gene cause myopathy with hyperCKemia

L Salzer‐Sheelo, A Fellner, N Orenstein… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Muscular A‐type lamin‐interacting protein (MLIP) is most
abundantly expressed in cardiac and skeletal muscle. In vitro and animal studies have …

MicroRNA205: A Key Regulator of Cardiomyocyte Transition from Proliferative to Hypertrophic Growth in the Neonatal Heart

JJ Weldrick, R Yi, LA Megeney, PG Burgon - International Journal of …, 2024 - mdpi.com
The mammalian myocardium grows rapidly during early development due to cardiomyocyte
proliferation, which later transitions to cell hypertrophy to sustain the heart's postnatal …

Novel homozygous nonsense mutation of MLIP and compensatory alternative splicing

J Mezreani, S Audet, F Martin, J Charbonneau… - NPJ Genomic …, 2022 - nature.com
Despite the growing accessibility of clinical sequencing, functional interpretation of variants
remains a major hurdle to molecular diagnostics of Mendelian diseases. We aimed to …

Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism

Q Yang, Y Zhai, H Wang, Y Cai, X Ma, Y Yin, Y Li… - Cell Reports, 2021 - cell.com
The hippocampus is one of two niches in the mammalian brain with persistent neurogenesis
into adulthood. The neurogenic capacity of hippocampal neural stem cells (NSCs) declines …

A novel MLIP truncating variant in an 80-year-old patient with late-onset progressive weakness

L Bermejo-Guerrero, A Arteche-López… - Brain, 2022 - academic.oup.com
The MLIP gene (* 614106) encodes the muscular lamin A/C-interacting protein and has its
highest expression level in cardiac muscle, skeletal muscle and the brain. It has been linked …

MLIP-Associated Myopathy: A Case Report and Review of the Literature

F Al Amrani, K Al-Thihli… - Journal of …, 2023 - content.iospress.com
Background: Muscular A-type lamin-interacting protein (MLIP) has a regulatory role in
myoblast differentiation and organization of myonuclear positioning in skeletal muscle. It is …