Cholesterol biosynthesis: a mechanistic overview
NM Cerqueira, EF Oliveira, DS Gesto… - Biochemistry, 2016 - ACS Publications
Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …
Enzymes of the mevalonate pathway of isoprenoid biosynthesis
HM Miziorko - Archives of biochemistry and biophysics, 2011 - Elsevier
The mevalonate pathway accounts for conversion of acetyl-CoA to isopentenyl 5-
diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The …
diphosphate, the versatile precursor of polyisoprenoid metabolites and natural products. The …
Structural mechanism for statin inhibition of HMG-CoA reductase
ES Istvan, J Deisenhofer - Science, 2001 - science.org
HMG-CoA (3-hydroxy-3-methylglutaryl–coenzyme A) reductase (HMGR) catalyzes the
committed step in cholesterol biosynthesis. Statins are HMGR inhibitors with inhibition …
committed step in cholesterol biosynthesis. Statins are HMGR inhibitors with inhibition …
Regulation of HMG-CoA reductase in mammals and yeast
JS Burg, PJ Espenshade - Progress in lipid research, 2011 - Elsevier
HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a
rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …
rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …
The role of structure and biophysical properties in the pleiotropic effects of statins
Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are
amongst the most prescribed medications worldwide. Most statins work as a competitive …
amongst the most prescribed medications worldwide. Most statins work as a competitive …
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
JA Friesen, VW Rodwell - Genome biology, 2004 - Springer
Summary The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is …
catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is …
The biosynthesis of C 5–C 25 terpenoid compounds
PM Dewick - Natural product reports, 2002 - pubs.rsc.org
Covering: 1998–2000. Previous review: Nat. Prod. Rep., 1999, 16, 97This review covers
recently-published experimental information on the biosynthesis of terpenoids in the range …
recently-published experimental information on the biosynthesis of terpenoids in the range …
[HTML][HTML] Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
ES Istvan, M Palnitkar, SK Buchanan… - The EMBO …, 2000 - embopress.org
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate,
the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is …
the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is …
Improved prediction of protein–protein binding sites using a support vector machines approach
JR Bradford, DR Westhead - Bioinformatics, 2005 - academic.oup.com
Motivation: Structural genomics projects are beginning to produce protein structures with
unknown function, therefore, accurate, automated predictors of protein function are required …
unknown function, therefore, accurate, automated predictors of protein function are required …
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci
EI Wilding, JR Brown, AP Bryant, AF Chalker… - Journal of …, 2000 - Am Soc Microbiol
The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)–pyruvate pathway are
alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl …
alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl …