Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

Background Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous
autoimmune disease. A variety of immunological defects contribute to SLE, including …

PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

The trafficking of leukocytes into and within lymphoid and peripheral tissues is central to
immune cell development, immunosurveillance and effector function. Interstitial leukocyte …

Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease that
results from a break in immune tolerance to self-antigens, leading to multi-organ destruction …