Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …

Inflammasomes are signalling platforms that sense a diverse range of microbial products
and also a number of stress and damage associated endogenous signals. Inflammasome …

The inflammasome is a signalling platform leading to caspase-1 activation. Caspase-1
causes pyroptosis, a necrotic-like cell death. AIM2 is an inflammasome sensor for cytosolic …

The importance of T helper type 1 (Th1) cell immunity in host resistance to the intracellular
bacterium Francisella tularensis is well established. However, the relative roles of interleukin …

Lactobacillus plantarum DK119 (DK119) isolated from the fermented Korean cabbage food
was used as a probiotic to determine its antiviral effects on influenza virus. DK119 intranasal …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …

Francisella tularensis is a highly virulent intracellular pathogen that invades and replicates
within numerous host cell types including macrophages, hepatocytes and pneumocytes. By …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

In recent years, studies on the intracellular pathogen Francisella tularensis have greatly
intensified, generating a wealth of new information on the interaction of this organism with …