The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …

Over the last decade fundamentally new features have been revealed for the participation of
glutathione and glutathione-dependent enzymes (glutathione transferase and glutaredoxin) …

Work during the past 14 years has shown that mitochondria are the primary site for the
biosynthesis of iron–sulfur (Fe/S) clusters. In fact, it is this process that renders mitochondria …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Patients with nonketotic hyperglycinemia and deficient glycine cleavage enzyme activity, but
without mutations in AMT, GLDC or GCSH, the genes encoding its constituent proteins …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

Важную роль для жизнеспособности клетки играет контроль мета болизма и процессов
развития, в значительной степени осуществля емый за счет тиол-дисульфидного …