The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle
progression during mitosis with the state of chromosome attachment to the mitotic spindle …

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

During cell division, chromosome congression to the spindle center, their orientation along
the spindle long axis and alignment at the metaphase plate depend on interactions between …

In the eukaryotic cell cycle, a threshold level of cyclin B accumulation triggers the G2-to-M
transition, and subsequent cyclin B destruction triggers mitotic exit. The anaphase-promoting …

Accurate chromosome segregation is required for cell survival and organismal development.
During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high …

During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle
microtubules. 1, 2 Kinetochores also function as signaling hubs directing mitotic progression …

During cell division, genome inheritance is orchestrated by microtubule attachments formed
at kinetochores of mitotic chromosomes. The primary microtubule coupler at the kinetochore …

During cell division, chromosome segregation is orchestrated by a microtubule-based
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …

The spindle assembly checkpoint (SAC) is a surveillance mechanism contributing to the
preservation of genomic stability by monitoring the microtubule attachment to, and/or the …