Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …

G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four
guanines fold in a planar arrangement through Hoogsteen hydrogen bonds. Although many …

The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by
coronavirus (CoV) genomes and several regions of this protein are essential for viral …

Viruses are the most abundant organisms on our planet, affecting all living beings: some of
them are responsible for massive epidemics that concern health, national economies and …

G4 DNA is a non-canonical DNA structure consisting of a stacked array of Gquartets held
together by base pairing between guanine bases. The formation of G4 DNA requires a …

G-quadruplexes are non-canonical nucleic-acid structures that control transcription,
replication, and recombination in organisms. G-quadruplexes are present in eukaryotes …

Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to
suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that …

A G-quadruplex (G4) is a four-stranded nucleic acid secondary structure maintained by
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …