Since the 1990s, α-oxo aldehyde or glyoxylic acid chemistry has inspired a vast array of
synthetic tools for tailoring peptide or protein structures, for developing peptides endowed …

Proteins that engage in intracellular interactions with other proteins are widely considered
among the most biologically appealing yet chemically intractable targets for drug discovery …

This report demonstrates the feasibility of surface-initiated atom transfer radical
polymerization to prepare thin polymer layers (“brushes”) that can be functionalized with …

Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy Angew …

Optimized coupling protocols are presented for the efficient and automated generation of
carboxyfluorescein-labeled peptides. Side products, generated when applying earlier …

Small ubiquitin-like modifier (SUMO) post-translational modification (PTM) of proteins has a
crucial role in the regulation of important cellular processes. This protocol describes the …

Mitochondria play central roles in maintaining cellular metabolic homeostasis, cell survival
and cell death, and generate most of the cell's energy. Mitochondria maintain their …

US7371719B2 - Self-assembly of peptide-amphiphile nanofibers under physiological conditions
- Google Patents US7371719B2 - Self-assembly of peptide-amphiphile nanofibers under …

We report a novel generation of peptide arrays fabricated by site-specific ligation of glyoxylyl
peptides onto glass slides covered by a semicarbazide sol− gel layer. These arrays allowed …

Combining fluorescent zinc sensors with the facile syntheses and biological targeting
capabilities of peptides, we created green-and blue-emitting probes that (i) are readily …