Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Lysosomes degrade and recycle macromolecules that are delivered through the
biosynthetic, endocytic, and autophagic routes. Hydrolysis of the different classes of …

The rapid growth of materials chemistry data, driven by advancements in large-scale
radiation facilities as well as laboratory instruments, has outpaced conventional data …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and it
is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra …

ABSTRACT Interferon-gamma (IFN-γ) is a major effector molecule of immunity and a
common feature of tumors responding to immunotherapy. Active IFN-γ signaling can directly …

The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

Glioblastoma is hard to be eradicated partly because of the obstructive blood–brain barrier
(BBB) and the dynamic autophagy activities of glioblastoma. Here, hydroxychloroquine …

To fulfill their function, pancreatic beta cells require precise nutrient‐sensing mechanisms
that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have …

Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome
characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and …

Aging processes, including immunosenescence, inflammation, inflammasome formation,
genomic instability, telomeric attrition, and altered autophagy, are involved in viral infections …