A review: FDA-approved fluorine-containing small molecules from 2015 to 2022
N Sheikhi, M Bahraminejad, M Saeedi… - European Journal of …, 2023 - Elsevier
Fluorine-containing small molecules have occupied an especial position in drug discovery
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
Design, synthesis, anticancer activity of new amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids: An insights from molecular docking, molecular …
N Gariganti, SK Loke, E Pagadala, P Chinta… - Journal of Molecular …, 2023 - Elsevier
A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …
have been synthesized and their structures were confirmed by using spectroscopic …
Structure-based drug design of RdRp inhibitors against SARS-CoV-2
K Shehzadi, A Saba, M Yu, J Liang - Topics in Current Chemistry, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …
New bis hydrazone: synthesis, X-ray crystal structure, DFT computations, conformational study and in silico study of the inhibition activity of SARS-CoV-2
A Tabbiche, A Bouchama, N Chafai, F Zaidi… - Journal of Molecular …, 2022 - Elsevier
The aim of this work was to synthesize new bis hydrazone derived from benzil in good yield,
namely:(1Z, 2Z)-1, 2-bis (3-Chlorophenyl Hydrazino) Benzil, encoded by 3-Cl BHB. The …
namely:(1Z, 2Z)-1, 2-bis (3-Chlorophenyl Hydrazino) Benzil, encoded by 3-Cl BHB. The …
Structural and reactivity studies of pravadoline–An ionic liquid, with reference to its wavefunction-relative properties using DFT and MD simulation
Pharmaceuticals are important in medical care because they improve life quality and extend
life expectancy, particularly in chronic diseases. Pravadoline is a non-steroidal anti …
life expectancy, particularly in chronic diseases. Pravadoline is a non-steroidal anti …
[HTML][HTML] Inhibitory effect of anti-HIV compounds extracted from Indian medicinal plants to retard the replication and transcription process of SARS-CoV-2: an insight …
Abstract Outbreak of Coronavirus (SARS-CoV-2) has thrown a big challenge to the globe by
snatching millions of human lives from the world. In this study, inhibitory efficiency of ten anti …
snatching millions of human lives from the world. In this study, inhibitory efficiency of ten anti …
Synthesis and Characterization of Zn (II) Complex of 4-chloro-2-(((2-phenoxyphenyl) imino) methyl) phenol and its Biological Efficacies: DNA Interaction, ADMET, DFT …
UK Singha, S Pradhan, P Gurung, P Chhetri… - Journal of …, 2024 - Springer
Abstract Condensing 2-phenoxyaniline with 5-chlorosalicyldehyde under reflux conditions, a
4-chloro-2-(((2-phenoxyphenyl) imino) methyl) phenol Schiff base has been Synthesized. A …
4-chloro-2-(((2-phenoxyphenyl) imino) methyl) phenol Schiff base has been Synthesized. A …
Synthesis, spectroscopic characterization of novel phthalimides derivatives bearing a 1, 2, 3-triazole unit and examination as potential SARS-CoV-2 inhibitors via in …
A Tan - Journal of Molecular Structure, 2022 - Elsevier
In the present study, novel phthalimide derivatives 8 (af) and 9 (af) bearing a 1, 2, 3-triazole
subunit were synthesized via CuAAC reactions and characterized by 1 H, 13 C NMR, HR …
subunit were synthesized via CuAAC reactions and characterized by 1 H, 13 C NMR, HR …
Encapsulated hydroxychloroquine and chloroquine into cyclic oligosaccharides are the potential therapeutics for COVID-19: insights from first-principles calculations
Abstract Novel-Coronavirus (COVID-19) outburst has become a worldwide pandemic which
threaten the scientific community to design and discover efficient and effective treatment …
threaten the scientific community to design and discover efficient and effective treatment …