Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

The deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose
homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Introduction Semaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved
for treatment of type 2 diabetes mellitus and is available in subcutaneous and oral dosage …

The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is
currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride …

Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its
numerous clinical complications are related to mitochondrial dysfunction and oxidative …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus and currently one of
the major causes of blindness. Several previous studies have demonstrated that autophagy …