Animal models of Alzheimer's disease and frontotemporal dementia
Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
Mitochondrial dysfunction-the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity
The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
V Rhein, X Song, A Wiesner, LM Ittner… - Proceedings of the …, 2009 - National Acad Sciences
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ)-containing plaques,
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …
neurofibrillary tangles, and neuron and synapse loss. Tangle formation has been …
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-β
N Schonrock, YD Ke, D Humphreys, M Staufenbiel… - PloS one, 2010 - journals.plos.org
Normal brain development and function depends on microRNA (miRNA) networks to fine
tune the balance between the transcriptome and proteome of the cell. These small non …
tune the balance between the transcriptome and proteome of the cell. These small non …
Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease
Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin
resistance, or both. There is increasing evidence that insulin also plays a role in Alzheimer's …
resistance, or both. There is increasing evidence that insulin also plays a role in Alzheimer's …
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
In Alzheimer disease (AD) and frontotemporal dementia the microtubule-associated protein
Tau becomes progressively hyperphosphorylated, eventually forming aggregates. However …
Tau becomes progressively hyperphosphorylated, eventually forming aggregates. However …
Tau‐targeted treatment strategies in Alzheimer's disease
With populations ageing worldwide, the need for treating and preventing diseases
associated with high age is pertinent. Alzheimer's disease (AD) is reaching epidemic …
associated with high age is pertinent. Alzheimer's disease (AD) is reaching epidemic …
A decade of tau transgenic animal models and beyond
The first tau transgenic mouse model was established more than a decade ago. Since then,
much has been learned about the role of tau in Alzheimer's disease and related disorders …
much has been learned about the role of tau in Alzheimer's disease and related disorders …
Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction
YA Lim, V Rhein, G Baysang, F Meier, A Poljak… - …, 2010 - Wiley Online Library
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are leading causes of
morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition …
morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition …
Insights into mitochondrial dysfunction: aging, amyloid-β, and tau–a deleterious trio
Significance: Alzheimer's disease (AD) is an age-related progressive neurodegenerative
disorder mainly affecting elderly individuals. The pathology of AD is characterized by …
disorder mainly affecting elderly individuals. The pathology of AD is characterized by …