Since our previous review, 1 there has been a tremendous development in the field of
carbazole alkaloids. New synthetic methodologies have been developed, existing …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4)(IC50, 0.011
μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional …

The mechanism (s) by which Lactobacillus-dominated cervicovaginal microbiota provide a
barrier to Chlamydia trachomatis infection remain (s) unknown. Here we evaluate the impact …

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood
coordination of cell cycle progression and execution of cell fate choices. Using existing …

The cyclin-dependent kinase (CDK) family of serine/threonine kinases regulate progression
through each stage of the cell division cycle and as such are major targets for deregulation …

Abstract Reaction of 5-morphilinosulfonylisatin (1) with acetophenones (2a–e) afforded 3-
hydroxy-3-substituted-2-oxoindoles 3a-e, when treated with acetic acid the expected 3 …

An intricate link is becoming apparent between metabolism and cellular identities. Here, we
explore the basis for such a link in an in vitro model for early mouse embryonic …

Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide
an effective method for the treatment of proliferative diseases such as cancer. The pyrido [2 …

Total body irradiation (TBI) can induce lethal myelosuppression, due to the sensitivity of
proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR). No …