In vitro generation of hematopoietic cells and especially hematopoietic stem cells (HSCs)
from human pluripotent stem cells (PSCs) are subject to intensive research in recent …

Inherited blood disorders comprise a large spectrum of diseases due to germline mutations
in genes with key function in the hematopoietic system; they include immunodeficiencies …

Natural killer (NK) cells are a critical component of the innate immune system. However,
their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs …

SOX17 has been implicated in arterial specification and the maintenance of hematopoietic
stem cells (HSCs) in the murine embryo. However, knowledge about molecular pathways …

The ability to manufacture human hematopoietic stem cells (HSCs) in the laboratory holds
enormous promise for cellular therapy of human blood diseases. Several differentiation …

Over the past decade, enormous progress has been made in the field of induced pluripotent
stem cells (iPSCs). Patients' somatic cells such as skin fibroblasts or blood cells can be used …

The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …

Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de
novo production of blood cells for transfusion, immunotherapies, and transplantation …

Despite a substantial appreciation for the critical role of macrophages in cardiometabolic
diseases, understanding of human macrophage biology has been hampered by the lack of …