Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems
have revolutionized traditional gene-editing tools and are a significant tool for ameliorating …

Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …

Induced pluripotent stem cells (iPSCs) offer great promise in the areas of disease modeling,
basic research, drug development, and regenerative medicine. Much of their value comes …

Gastrulation is the fundamental process during the embryogenesis of all multicellular
animals through which the basic body plan is first laid down. It is pivotal in generating …

Abstract Background Haematopoietic stem cells (HSCs) first arise during development in the
aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic …

Cell cycle progression is linked to transcriptome dynamics and variations in the response of
pluripotent cells to differentiation cues, mostly through unknown determinants. Here, we …

Mechanisms specifying amniotic ectoderm and surface ectoderm are unresolved in humans
due to their close similarities in expression patterns and signal requirements. This lack of …

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by the expansion of
CAG repeats in exon 1 of the huntingtin gene (HTT). Despite its monogenic nature, HD …

The human CST complex composed of CTC1, STN1, and TEN1 is critically involved in
telomere maintenance and homeostasis. Specifically, CST terminates telomere extension by …

Animal or human models recapitulating brain ribosomopathies are incomplete, hampering
development of urgently needed therapies. Here, we generated genetic mouse and human …