Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

Horizontal gene transfer among host-associated microbes

JM de Sousa, M Lourenço, I Gordo - Cell Host & Microbe, 2023 - cell.com
Horizontal gene transfer is an important evolutionary force, facilitating bacterial diversity. It is
thought to be pervasive in host-associated microbiomes, where bacterial densities are high …

[HTML][HTML] Expanding known viral diversity in the healthy infant gut

SA Shah, L Deng, J Thorsen, AG Pedersen… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

[HTML][HTML] Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

S Nishijima, N Nagata, Y Kiguchi, Y Kojima… - Nature …, 2022 - nature.com
Indigenous bacteriophage communities (virome) in the human gut have a huge impact on
the structure and function of gut bacterial communities (bacteriome), but virome variation at a …

Phage-inclusive profiling of human gut microbiomes with Phanta

Y Pinto, M Chakraborty, N Jain, AS Bhatt - Nature Biotechnology, 2024 - nature.com
Due to technical limitations, most gut microbiome studies have focused on prokaryotes,
overlooking viruses. Phanta, a virome-inclusive gut microbiome profiling tool, overcomes the …

[HTML][HTML] Minnesota peat viromes reveal terrestrial and aquatic niche partitioning for local and global viral populations

AM Ter Horst, C Santos-Medellín, JW Sorensen… - Microbiome, 2021 - Springer
Background Peatlands are expected to experience sustained yet fluctuating higher
temperatures due to climate change, leading to increased microbial activity and greenhouse …

[HTML][HTML] Unraveling the viral dark matter through viral metagenomics

TM Santiago-Rodriguez, EB Hollister - Frontiers in immunology, 2022 - frontiersin.org
Viruses are part of the microbiome and have essential roles in immunology, evolution,
biogeochemical cycles, health, and disease progression. Viruses influence a wide variety of …

[HTML][HTML] Advances and challenges in cataloging the human gut virome

J Li, F Yang, M Xiao, A Li - Cell Host & Microbe, 2022 - cell.com
The human gut virome, which is often referred to as the" dark matter" of the gut microbiome,
remains understudied. A better understanding of the composition and variations of the gut …

[HTML][HTML] Factors affecting variation of the human gut phageome

CA Tobin, C Hill, AN Shkoporov - Annual Review of …, 2023 - annualreviews.org
The gut microbiome is a dense and metabolically active consortium of microorganisms and
viruses located in the lower gastrointestinal tract of the human body. Bacteria and their …

Cargo Genes of Tn7-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes

S Benler, G Faure, H Altae-Tran, S Shmakov, F Zhang… - MBio, 2021 - Am Soc Microbiol
Transposition is a major mechanism of horizontal gene mobility in prokaryotes. However,
exploration of the genes mobilized by transposons (cargo) is hampered by the difficulty in …