Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the
superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises 4 …

Migraine is a strongly disabling disease characterized by a unilateral throbbing headache
lasting for up to 72 h for each individual attack. There have been many theories on the …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

The generation of human sensory neurons by directed differentiation of pluripotent stem
cells opens new opportunities for investigating the biology of pain. The inability to generate …

Diabetic patients frequently suffer from continuous pain that is poorly treated by currently
available analgesics. We used mouse models of type 1 and type 2 diabetes to investigate a …