DNA replication during cell proliferation is 'vertical'copying, which reproduces an initial
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …

Polyploid cells demonstrate biological plasticity and stress adaptation in evolution;
development; and pathologies, including cardiovascular diseases, neurodegeneration, and …

Aims Pre-term birth affects 10–12% of live births and occurs when the myocardium is still
developing; therefore, the final structure of the myocardium could be altered. We …

Mother–child cohort studies have established that both pre‐pregnancy body mass index
(BMI) and gestational weight gain are independently associated with cardio‐metabolic risk …

A primary limitation in the use of pluripotent stem cell‐derived cardiomyocytes (PSC‐CMs)
for both patient health and scientific investigation is the failure of these cells to achieve full …

Glucocorticoids are essential in mammals to mature fetal organs and tissues in order to
survive after birth. Hence, antenatal glucocorticoid treatment (termed antenatal corticosteroid …

World‐wide epidemiological and experimental animal studies demonstrate that adversity in
fetal life, resulting in intrauterine growth restriction, programmes the offspring for a greater …

Embryo-environment interactions affecting cardio-respiratory development in vertebrates
have been extensively studied, but an equally extensive conceptual framework for …

Polyploid cells show great among-species and among-tissues diversity and relation to
developmental mode, suggesting their importance in adaptive evolution and developmental …

The dependence of cancer on overexpressed c-MYC and its predisposition for polyploidy
represents a double puzzle. We address this conundrum by cross-species transcription …