Mass spectrometry imaging with high resolution in mass and space

A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

Imaging mass spectrometry: instrumentation, applications, and combination with other visualization techniques

A Bodzon‐Kulakowska, P Suder - Mass spectrometry reviews, 2016 - Wiley Online Library
Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It
has unique ability to identify structures and to unravel molecular changes that occur in the …

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

JG Swales, G Hamm, MR Clench… - International Journal of …, 2019 - Elsevier
Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

MALDI‐imaging mass spectrometry–an emerging technique in plant biology

S Kaspar, M Peukert, A Svatos, A Matros… - Proteomics, 2011 - Wiley Online Library
Recent advances in instrumentation and sample preparation have facilitated the mass
spectrometric (MS) imaging of a large variety of biological molecules from small metabolites …

1, 5-Diaminonaphthalene hydrochloride assisted laser desorption/ionization mass spectrometry imaging of small molecules in tissues following focal cerebral …

H Liu, R Chen, J Wang, S Chen, C Xiong… - Analytical …, 2014 - ACS Publications
A sensitive analytical technique for visualizing small endogenous molecules simultaneously
is of great significance for clearly elucidating metabolic mechanisms during pathological …

High‐speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling

BM Prentice, CW Chumbley… - Journal of Mass …, 2015 - Wiley Online Library
A matrix‐assisted laser desorption/ionization time of flight/time of flight tandem mass
spectrometer (MALDI TOF/TOF) has been used for high‐speed precursor/fragment ion …

Matrix-assisted laser desorption ionization mass spectrometry imaging for peptide and protein analyses: a critical review of on-tissue digestion

B Cillero-Pastor, RMA Heeren - Journal of proteome research, 2014 - ACS Publications
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has
established itself among the plethora of mass spectrometry applications. In the biomedical …

Sample preparation and fractionation techniques for intact proteins for mass spectrometric analysis

SL Thomas, JB Thacker, KA Schug… - Journal of Separation …, 2021 - Wiley Online Library
The analysis of proteins in biological samples is highly desirable, given their connection to
myriad biological functions and disease states, as well as the growing interest in the …

Tamm-Horsfall protein regulates mononuclear phagocytes in the kidney

R Micanovic, S Khan, D Janosevic… - Journal of the …, 2018 - journals.lww.com
Abstract Tamm–Horsfall protein (THP), also known as uromodulin, is a kidney-specific
protein produced by cells of the thick ascending limb of the loop of Henle. Although …