Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is
medicated by genetic, immune, and environmental factors. At least 66 different kinds of …

Lymphocytes involved in intestinal immune response are found in organized immune
inductive sites of the gut-associated lymphoid tissues (GALT) such as Peyer's patches (PP) …

Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular
studies are lacking. Candidate regulatory molecules localized within the tight junction (TJ) …

There are now many experimental models of inflammatory bowel disease (IBD), most of
which are due to induced mutations in mice that result in an impaired homeostasis with the …

Therapeutic promotion of intestinal regeneration holds great promise, but defining the
cellular mechanisms that influence tissue regeneration remains an unmet challenge. To …

Memory B cells are more heterogeneous than previously thought. Given that B cells play
powerful antibody-independent effector functions, it seems reasonable to assume division of …

Oral infection of susceptible mice with Toxoplasma gondii results in Th1-type
immunopathology in the ileum. We investigated gut flora changes during ileitis and …

Mycobacterium tuberculosis remains a major public health burden. It is generally thought
that while B cell-and antibody-mediated immunity plays an important role in host defense …

Peroral infection with Toxoplasma gondii leads to the development of small intestinal
inflammation dependent on Th1 cytokines. The role of Th17 cells in ileitis is unknown. We …

Objective Recent data suggest that the reconstituting peripheral B cell compartment after B
cell depletion therapy may be functionally immature, with a preponderance of transitional B …