Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Objective To better define the rare adverse event (AE) of diabetes mellitus associated with
immune checkpoint inhibitors (ICIs). Design and methods We report the case of a lung …

Targeted blockade of the checkpoint molecule programmed cell death 1 (PD-1) can activate
tumor-specific T cells to destroy tumors, whereas targeted potentiation of PD-1 is expected to …

Autoimmune diabetes mellitus is a rare but significant side effect of treatment with immune
checkpoint inhibitors. Immune checkpoint inhibitor-induced diabetes mellitus (CPI-DM) is …

It is increasingly appreciated that the pathogenic mechanisms of type 1 diabetes involve
both the autoimmune aggressors and their beta cell targets, which engage in a conflicting …

Metastasis and immune suppression account for the poor prognosis of oral squamous cell
carcinoma (OSCC). YKT6 is a member of the soluble NSF attachment protein receptor …

Abstract Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic
individuals, and its expression and signaling are regulated by T1D genetic risk variants and …