Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

In Parkinson's disease and some atypical Parkinson's syndromes, aggregation of the α-
synuclein protein (α-syn) has been linked to neurodegeneration. Many triggers for …

The protein α-Synuclein (αS) is linked to Parkinson's disease through its abnormal
aggregation, which is thought to involve cytosolic and membrane-bound forms of αS …

Parkinson's disease (PD) is a common neurodegenerative disease which usually associates
with neuroinflammation. The main pathological characteristics of PD are dopaminergic …

In the cell, the conformations of nascent polypeptide chains during translation are modulated
by both the ribosome and its associated molecular chaperone, trigger factor. The specific …

α-Synuclein (αSyn) constitutes the main protein component of Lewy bodies, which are the
pathologic hallmark in Parkinson's disease. αSyn is unstructured in solution but the …

Recent studies revealed that molecular events related with the physiology and pathology of
αS might be regulated by specific sequence motifs in the primary sequence of αS. The …

The spontaneous self-assembly of α-synuclein (α-syn) into aggregates of different
morphologies is associated with the development of Parkinson's disease. However, the …

Human alpha-Synuclein (aS), implicated in Parkinson's disease, adopts a rich variety of
different conformations depending on the macromolecular context. In order to unravel its …

Parkinson's disease can manifest either as a sporadic form, which is common, or as an
inherited autosomal dominant trait resulting from missense mutations. Recently, the novel α …