Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal
layers. The initiating factors and clinical consequences depend on the underlying disease …

At the early stage of chronic kidney disease (CKD), the systemic mineral metabolism and
bone composition start to change. This alteration is known as chronic kidney disease …

Klotho is a potent regulator of 1, 25-hydroxyvitamin D3 [1, 25 (OH) 2D3] formation and
calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer from severe …

Rotator cuff injuries are a common clinical problem either as a result of overuse or aging.
Biological approaches to tendon repair that involve use of scaffolding materials or cell …

The phenotypic transformation from differentiated to dedifferentiated vascular smooth
muscle cells (VSMCs) plays a crucial role in VSMC proliferation and vascular remodeling in …

Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality
in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive …

Patients with CKD have accelerated vascular stiffening contributing significantly to excess
cardiovascular morbidity and mortality. Much of the arterial stiffening is thought to involve …

It is now well established that hypertension is accompanied by remodeling of the arterial
wall with significant modifications in extracellular matrix composition and in vascular cell …

In chronic kidney disease (CKD), increased plasma phosphate concentrations cause
vascular calcification which substantially contribute to cardiovascular events and increased …

Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly
smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors …