Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
[HTML][HTML] NTM drug discovery: status, gaps and the way forward
Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
[HTML][HTML] Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
PL Lin, CB Ford, MT Coleman, AJ Myers, R Gawande… - Nature medicine, 2014 - nature.com
Over 30% of the world's population is infected with Mycobacterium tuberculosis (Mtb), yet
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
[PDF][PDF] High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting, 28-29 April 2014, Geneva, Switzerland
World Health Organization - 2014 - apps.who.int
Executive summary Globally, one third of all tuberculosis (TB) cases are not notified, and
many patients' samples do not undergo drug-susceptibility testing (DST). To achieve the …
many patients' samples do not undergo drug-susceptibility testing (DST). To achieve the …
A systematic review of biomarkers to detect active tuberculosis
Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …
[HTML][HTML] Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
[HTML][HTML] In search of a new paradigm for protective immunity to TB
C Nunes-Alves, MG Booty, SM Carpenter… - Nature Reviews …, 2014 - nature.com
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …
results are starting to come in. Some of these results are not so encouraging, as exemplified …
The mycobacterial cell envelope—lipids
M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …
New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
About 1· 3 million people died of tuberculosis in 2012, despite availability of effective drug
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …
[HTML][HTML] Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis
Background Tuberculosis (TB) continues to be a critical global health problem, which killed
millions of lives each year. Certain circulating cell subsets are thought to differentially …
millions of lives each year. Certain circulating cell subsets are thought to differentially …